One Canal by Breakthrough

Breakthrough Properties, a leading global developer, owner, and operator of life sciences real estate, acquired One Canal in 2021 to transform it into a world-class life science research center catering to biotech companies in the heart of Cambridge’s renowned innovation hub.

Originally built in 1983 and recently renovated in 2015, One Canal’s goal was to reposition it as a new, modern lab and office space. This transformation emphasizes not only high-quality architectural and interior design, exceptional hospitality, and exemplary operational excellence but also a strong commitment to sustainability, as evidenced by its pursuit of LEED Gold, Fitwel, and WELL certifications.

After providing comprehensive due diligence support, TRIA began designing the building with a new lobby, fitness center, restrooms, storage room, and loading dock. It also required new infrastructure that could support future tenants’ scientific research, including a new roof infrastructure, a new first-floor base building mechanical room, an expanded first-floor electrical room, new lab shafts supporting central utilities and exhaust air, a new freight elevator, loading dock expansion,  lab and office pipe chases, and more.  TRIA continued with the fit-out of speculative suites.

Influenced by the adjacent Lechmere Canal Park, the hospitality-centric design concept focuses on blending art and science into modern yet natural sophistication. In addition to the flexible spec lab and office layouts, where scientists can glimpse the Museum of Science and Charles River, the amenities include a modern lounge, collaboration spaces on two floors, a unique winter garden that provides a serene escape, and a high-quality fitness center equipped with state-of-the-art facilities.

project location

Cambridge, MA

Project size

112,000  SF

services

Building Repositioning
Planning & Programming
Lab Design
Renderings
Interior Design
Sustainable Design

Breakthrough Properties, a leading global developer, owner, and operator of life sciences real estate, acquired One Canal in 2021 to transform it into a world-class life science research center catering to biotech companies in the heart of Cambridge’s renowned innovation hub.

Originally built in 1983 and recently renovated in 2015, One Canal’s goal was to reposition it as a new, modern lab and office space. This transformation emphasizes not only high-quality architectural and interior design, exceptional hospitality, and exemplary operational excellence but also a strong commitment to sustainability, as evidenced by its pursuit of LEED Gold, Fitwel, and WELL certifications.

After providing comprehensive due diligence support, TRIA began designing the building with a new lobby, fitness center, restrooms, storage room, and loading dock. It also required new infrastructure that could support future tenants’ scientific research, including a new roof infrastructure, a new first-floor base building mechanical room, an expanded first-floor electrical room, new lab shafts supporting central utilities and exhaust air, a new freight elevator, loading dock expansion,  lab and office pipe chases, and more.  TRIA continued with the fit-out of speculative suites.

Influenced by the adjacent Lechmere Canal Park, the hospitality-centric design concept focuses on blending art and science into modern yet natural sophistication. In addition to the flexible spec lab and office layouts, where scientists can glimpse the Museum of Science and Charles River, the amenities include a modern lounge, collaboration spaces on two floors, a unique winter garden that provides a serene escape, and a high-quality fitness center equipped with state-of-the-art facilities.

Via Separations

Via Separations, a climate-tech company, aims to promote a sustainable, resource-efficient future by eliminating energy usage in industrial processes. 

Focused on innovative filtration technology, Via’s space is mindful of its impact on its community.  The “Do More with Less” motto guided TRIA to fit out a workplace that is  “distilled to the simplest form.”  TRIA’s design preserves the existing natural materials in a 160-year-old, repositioned building while also providing employees with efficiency, adaptability, and comfort. Exposed wood columns, bricks and ceilings in the cafe, open office and collaboration areas showcase the beauty of the existing construction while also adhering to the company’s commitment to sustainability.  Designed as future-ready, Via can adjust to both anticipated and unforeseen changes, ensuring preparedness for rapid growth and expansion while advancing its research safely and effectively. 

TRIA provided solutions that encourage serendipitous moments for informal interactions. The collaborative space is divided into approximately 50% manufacturing, prototype, machine shop, and lab space, and 50% office, meeting and amenities spread over two floors.  Partnering with Columbia Construction, TRIA implemented a design-build schedule after extensive visioning and workplace strategy analysis. 

Project Location

Watertown, MA

Project Size

50,000 SF

Project services

Planning & Programming
Visioning
Interior Design

Via Separations, a climate-tech company, aims to promote a sustainable, resource-efficient future by eliminating energy usage in industrial processes. 

Focused on innovative filtration technology, Via’s space is mindful of its impact on its community.  The “Do More with Less” motto guided TRIA to fit out a workplace that is  “distilled to the simplest form.”  TRIA’s design preserves the existing natural materials in a 160-year-old, repositioned building while also providing employees with efficiency, adaptability, and comfort. Exposed wood columns, bricks and ceilings in the cafe, open office and collaboration areas showcase the beauty of the existing construction while also adhering to the company’s commitment to sustainability.  Designed as future-ready, Via can adjust to both anticipated and unforeseen changes, ensuring preparedness for rapid growth and expansion while advancing its research safely and effectively. 

TRIA provided solutions that encourage serendipitous moments for informal interactions. The collaborative space is divided into approximately 50% manufacturing, prototype, machine shop, and lab space, and 50% office, meeting and amenities spread over two floors.  Partnering with Columbia Construction, TRIA implemented a design-build schedule after extensive visioning and workplace strategy analysis. 

IQHQ – Innovation Park

Blending Nature and Modernism:  IQHQ’s Innovative Park Amenities

In the bustling landscape of industrial office parks, IQHQ stands out as an innovator, not just in its core operations but also in its approach to employee well-being. Located in the serene suburbs north of Boston, IQHQ sought to create an oasis for its employees, incorporating upscale amenities that harmonize with nature while embracing modern design principles.

Blending functionality with elegance. TRIA designed a full-service Class A kitchen/lounge and an upscale fitness center offering a retreat to employees on their 18-acre campus.

TRIA’s design philosophy revolved around bringing the outdoors inside. Large walls of windows offer panoramic views of lush greenery and a serene pond, creating a seamless connection between the interior and exterior spaces. Earthy tones and organic materials further enhance this connection, evoking a sense of tranquility and serenity.

The floor plan is thoughtfully designed to accommodate a variety of activities. Whether it’s dining, collaborating, or simply relaxing, employees have a plethora of seating options at their disposal. The coffee bar exudes sophistication with its bold patterned wall of oversized flowers in black and white.

In addition, a training room, featuring a neutral color palette and an organic wood slat ceiling, is conveniently located near the cafe integrating convenient relaxation or further collaboration.

The lower-level fitness amenity includes treadmills that line the perimeter, offering users the sensation of walking or running outdoors. There’s also a central zone of strength equipment, a yoga studio, locker rooms and a hydration break room.

Every aspect is designed to enhance employee well-being and foster a sense of connection with the natural world.

Project Location

Andover, MA

Project Size

27,000 SF

Project services

Planning & Programming
Visioning
Interior Design

Blending Nature and Modernism:  IQHQ’s Innovative Park Amenities

In the bustling landscape of industrial office parks, IQHQ stands out as an innovator, not just in its core operations but also in its approach to employee well-being. Located in the serene suburbs north of Boston, IQHQ sought to create an oasis for its employees, incorporating upscale amenities that harmonize with nature while embracing modern design principles.

Blending functionality with elegance. TRIA designed a full-service Class A kitchen/lounge and an upscale fitness center offering a retreat to employees on their 18-acre campus.

TRIA’s design philosophy revolved around bringing the outdoors inside. Large walls of windows offer panoramic views of lush greenery and a serene pond, creating a seamless connection between the interior and exterior spaces. Earthy tones and organic materials further enhance this connection, evoking a sense of tranquility and serenity.

The floor plan is thoughtfully designed to accommodate a variety of activities. Whether it’s dining, collaborating, or simply relaxing, employees have a plethora of seating options at their disposal. The coffee bar exudes sophistication with its bold patterned wall of oversized flowers in black and white.

In addition, a training room, featuring a neutral color palette and an organic wood slat ceiling, is conveniently located near the cafe integrating convenient relaxation or further collaboration.

The lower-level fitness amenity includes treadmills that line the perimeter, offering users the sensation of walking or running outdoors. There’s also a central zone of strength equipment, a yoga studio, locker rooms and a hydration break room.

Every aspect is designed to enhance employee well-being and foster a sense of connection with the natural world.

Confidential Client

This financial institution in the Back Bay of Boston needed a workplace that supported its new operational strategy, providing employees with mobility, flexibility, and a little fun too. They needed a collaborative, executive-style office that also offered opportunities for focus in both formal and informal areas.

To create a welcoming space, TRIA designed a floor plan that maximized the use of natural light. Warm tones coupled with a variety of zones that support different postures achieved the goal of promoting a healthy culture that is also supportive and innovative.  Visual and acoustic privacy were also high priorities. Equipped with planning ratios after interactive visioning workshops, TRIA programmed the space to include solo and duo rooms, focus workstations and pods, huddle rooms, along with larger open offices and meeting rooms. Design elements like the acoustic ceiling baffles and thoughtful textile choices contribute to an effort to maintain a cozy yet professional environment.

Project location

Boston, MA

Project Size

39,000 SF

Services

Planning & Programming
Workplace Evaluation
Visioning
Renderings
Interior Design

This financial institution in the Back Bay of Boston needed a workplace that supported its new operational strategy, providing employees with mobility, flexibility, and a little fun too. They needed a collaborative, executive-style office that also offered opportunities for focus in both formal and informal areas.

To create a welcoming space, TRIA designed a floor plan that maximized the use of natural light. Warm tones coupled with a variety of zones that support different postures achieved the goal of promoting a healthy culture that is also supportive and innovative.  Visual and acoustic privacy were also high priorities. Equipped with planning ratios after interactive visioning workshops, TRIA programmed the space to include solo and duo rooms, focus workstations and pods, huddle rooms, along with larger open offices and meeting rooms. Design elements like the acoustic ceiling baffles and thoughtful textile choices contribute to an effort to maintain a cozy yet professional environment.

Ring Therapeutics

Launched in 2017, Ring Therapeutics created a discovery and development platform that aims to usher in a new programmable medicine by harnessing the natural human commensal virome. It is now building a rich portfolio of therapeutic candidates targeting several areas.

As pioneers of the next generation of gene therapy, Ring was ready for its own space in Cambridge to embark on its mission. The new headquarters needed to support the staff’s creativity, energetic commitment and forward-thinking science. In addition, the CEO’s appreciation for nature, Japanese architecture and Zen philosophy needed to be incorporated into the overall design.

When TRIA became involved in the project, the building had just been repositioned for lab use. The new configuration resulted in a floor plan resembling a horseshoe shape. This curve—and the company’s agenda of disruption in the gene therapy space—allowed us to bend the rules in office standards.  As you walk on the main path, you can serendipitously pass through each of the zones that address the office and lab needs: Pause, Agile, Converse and Refresh. Focusing on access to natural light, the floor plan strikes a balance between defined private places to retreat and think and comfortable public spaces that foster impromptu collaboration and team connections.

Curved pathways, circular lighting, and rounded agile furniture provide a fun, lively, and engaging workspace. Felt baffling on the ceiling, playful lounge furniture, and oversized drum pendants modernize the space as creative innovation comes to life.

Our palette draws inspiration from the textures, colors, and tones found in Kyoto’s temple gardens to provide more context. We’ve strategically incorporated pops of color to define specific zones, such as feature walls, ceiling baffles, and furniture. These vibrant accents also take cues from Ring’s brand colors.

Ring Therapeutics CEO Tuyen Ong, MD, MBA. said, “I’ve appreciated the collaborative partnership with TRIA as we set out to create a space combining modern design with traditional Zen philosophy. It’s been tremendously rewarding to bring this to life and we hope this space will continue to inspire and energize us in our important mission.”

For more behind the scenes details, please click here to read our feature on The IIDA Designer Monologues.

Project location

Cambridge, MA

Project Size

65,000 GSF

Services

Planning & Programming
Lab Design
Workplace Evaluation
Visioning
Renderings
Video Flythrough
Interior Design

Launched in 2017, Ring Therapeutics created a discovery and development platform that aims to usher in a new programmable medicine by harnessing the natural human commensal virome. It is now building a rich portfolio of therapeutic candidates targeting several areas.

As pioneers of the next generation of gene therapy, Ring was ready for its own space in Cambridge to embark on its mission. The new headquarters needed to support the staff’s creativity, energetic commitment and forward-thinking science. In addition, the CEO’s appreciation for nature, Japanese architecture and Zen philosophy needed to be incorporated into the overall design.

When TRIA became involved in the project, the building had just been repositioned for lab use. The new configuration resulted in a floor plan resembling a horseshoe shape. This curve—and the company’s agenda of disruption in the gene therapy space—allowed us to bend the rules in office standards.  As you walk on the main path, you can serendipitously pass through each of the zones that address the office and lab needs: Pause, Agile, Converse and Refresh. Focusing on access to natural light, the floor plan strikes a balance between defined private places to retreat and think and comfortable public spaces that foster impromptu collaboration and team connections.

Curved pathways, circular lighting, and rounded agile furniture provide a fun, lively, and engaging workspace. Felt baffling on the ceiling, playful lounge furniture, and oversized drum pendants modernize the space as creative innovation comes to life.

Our palette draws inspiration from the textures, colors, and tones found in Kyoto’s temple gardens to provide more context. We’ve strategically incorporated pops of color to define specific zones, such as feature walls, ceiling baffles, and furniture. These vibrant accents also take cues from Ring’s brand colors.

Ring Therapeutics CEO Tuyen Ong, MD, MBA. said, “I’ve appreciated the collaborative partnership with TRIA as we set out to create a space combining modern design with traditional Zen philosophy. It’s been tremendously rewarding to bring this to life and we hope this space will continue to inspire and energize us in our important mission.”

For more behind the scenes details, please click here to read our feature on The IIDA Designer Monologues.

Vigil Neuroscience

Vigil Neuroscience is bringing the world’s first microglia-focused therapeutics to patients who suffer from rare and neurodegenerative diseases. While transforming the lives of patients, the staff wanted a robust and focused lab and office work space but also one that promoted unity and conversation. TRIA offered a diversity of spaces that fostered collaboration and community without losing sight of the importance of acoustic privacy to allow for concentrated work.

Across from the boardroom, a 3D interactive textile board became an opportunity to fulfill the CEO’s vision of engaging staff, visitors and patients to feel the positive effects of their daily work.

The lab space includes microscope room, tissue culture room, holding/procedure room and a glass wash/autoclave room. It also
satisfies LEED equivalent requirements in a newly constructed building in Arsenal Park.

Project Location

Watertown, MA

Project Size

19,000 SF

Services

Lab Programming & Planning
Visioning

Vigil Neuroscience is bringing the world’s first microglia-focused therapeutics to patients who suffer from rare and neurodegenerative diseases. While transforming the lives of patients, the staff wanted a robust and focused lab and office work space but also one that promoted unity and conversation.

Located in Boylston Properties Arsenal Yards Development, the light filled space offers sweeping  views of the Boston skyline. TRIA offered a diversity of spaces that fostered collaboration and community without losing sight of the importance of acoustic privacy to allow for concentrated work.

Across from the boardroom, a 3D interactive textile board became an opportunity to fulfill the CEO’s vision of engaging staff, visitors and patients to feel the positive effects of their daily work. The lab space includes microscope room, tissue culture room, holding/procedure room and a glass wash/autoclave room. It also satisfies LEED equivalent requirements in a newly constructed building in Arsenal Park.

Abata Therapeutics

When Abata realized that they were outgrowing their workplace in Cambridge, they capitalized on an opportunity to move its operations to Watertown, which allowed them to plan for further growth. The new construction at Arsenal Park provided them with summer views of the treetops and winter views of the Charles River. Because Abata is translated as “quiet place of peace,” the TRIA team utilized design details with this understated brand culture. The new tranquil office features an open concept with lots of natural light, preserved moss, and organic shapes to mimic the lines in the Abata logo. The interior lab glass walls feature glazing to provide semi privacy, while the exterior lab windows share views of Arsenal Park.

Project Location

Watertown, MA

Project size

24,000 SF

Project Type

Programming & Planning
Visioning
Interior Design

When Abata realized that they were outgrowing their workplace in Cambridge, they capitalized on an opportunity to move its operations to Watertown, which allowed them to plan for further growth. The new construction at Boylston Properties Arsenal Yards development provided them with summer views of the treetops and winter views of the Charles River. Because Abata is translated as “quiet place of peace,” the TRIA team utilized design details with this understated brand culture. The new tranquil office features an open concept with lots of natural light, preserved moss, and organic shapes to mimic the lines in the Abata logo. The interior lab glass walls feature glazing to provide semi privacy, while the exterior lab windows share views of Arsenal Park.

Vertex Pharmaceuticals

Vertex Pharmaceuticals is a global biotechnology company, located in Boston’s Innovation District, that invests in scientific innovation to create transformative medicines for people with serious diseases, with multiple approved medicines that treat the underlying cause of cystic fibrosis (CF,  and has several ongoing clinical and research programs in CF.

After a complete programming and planning effort to define Vertex’s requirement and workplace strategies, TRIA provided architectural services for The Jeffrey Leiden Center One for Cell and Genetic Therapies. The process, completed throughout the pandemic, was led by our lab-focused architect, who successfully implemented over 60 building changes to the original core and shell, which was originally designed for multiple tenants.

Achieving LEED Platinum certification, this new state-of-the-art facility, a “Workplace of the Future”, features labs and manufacturing operations. For the remaining 40% of the office space, Vertex utilizes neighborhood-based office space with quick huddle areas, large and small conference rooms, a large cafeteria with room for informal company meetings, a rooftop with sweeping views of the harbor and city, a fitness room, an IT bar, coffee bar and several kitchenettes.

This project was the topic of a panel discussion at  BisNow’s March 31, 2022 Boston Life Science Summit as a Case Study, Enhancing Urban Manufacturing.  To learn more, see our Insights. 

Location

Boston, MA

Size

268,000 SF

Services

New Buildout
Lab Design
Process Architecture
Workplace Evaluation
Visioning
Programming and Planning
Renderings
Sustainable Design
Interior Design

Vertex Pharmaceuticals is a global biotechnology company, located in Boston’s Innovation District, that invests in scientific innovation to create transformative medicines for people with serious diseases, with multiple approved medicines that treat the underlying cause of cystic fibrosis (CF) and has several ongoing clinical and research programs in CF.

After a complete programming and planning effort to define Vertex’s requirements and workplace strategies, TRIA provided architectural services for The Jeffrey Leiden Center One for Cell and Genetic Therapies. The process, completed throughout the pandemic, was led by our lab-focused architect who successfully implemented changes from an original multi-tenant design to a single one.

Achieving LEED Platinum certification, this new state-of-the-art facility, a “Workplace of the Future”, features labs and manufacturing operations. For the remaining 40% of the office space, Vertex utilizes neighborhood-based office space with quick huddle areas, large and small conference rooms, a large cafeteria with room for informal company meetings, a rooftop with sweeping views of the harbor and city, a fitness room, an IT bar, coffee bar and several kitchenettes.

This project was the topic of a panel discussion at  BisNow’s March 31, 2022 Boston Life Science Summit as a Case Study, Enhancing Urban Manufacturing.  To learn more, see our Insights. 

CRISPR Therapeutics

LOCATION

Framingham, MA

SIZE

45,000  SF

Services

Tenant Improvements
Lab and Office Fit Out
Site Selection
Visioning
Programming and Planning

2022 ISPE Facility of the Year Award Winner for Innovation!

CRISPR Therapeutics, a Switzerland-based gene-editing company, focuses on the development of transformative gene-based medicines for serious diseases. Continued success and anticipated annual growth created an opportunity for TRIA to create a highly innovative lab and office space near its new cGMP Manufacturing space.

This flexible, digitally-enabled facility is unique in utilizing a compact design with multiple independent production suites, each capable of producing a different product at a different stage of development while maintaining strict product segregation.

TRIA’s design task was to create an inspiring and cohesive facility that houses GMP manufacturing, but also labs, warehouses and supporting office and amenity spaces. It needed to be unique to the Framingham location while maintaining the brand integrity of its other locations.

Bringing individuality to the space was through lighting and wall graphics. Our design team created a large custom light fixture for their café space that is a replica of a compound. Abundant natural light and the use of glass walls provide a connection between office and manufacturing and promote interaction and collaboration.

Each of the labs has a unique wall covering, inspired by actual CRISPR cells and molecules. TRIA used photos of actual CRISPR cells and molecules, distorting the images while incorporating their colors bringing warmth and unique branding to a typically sterile environment.

Our team provided full services and delivered an award-winning lab and office, earning the 2022 ISPE Facility of the Year Award for Innovation. This annual program recognizes state-of-the-art projects utilizing new, innovative technologies to improve the quality of products, reduce the cost of producing high-quality medicines, and demonstrate advances in project delivery.

Scholar Rock

A clinical-stage biopharmaceutical company, Scholar Rock, was outgrowing its current space. TRIA was brought on board initially to provide visioning and programming/planning services and subsequently hired for the design to relocate their headquarters.  Scholar Rock’s new 50,000 SF space features a 45/55 lab and office split.

The design focused on implementing branding throughout the space and creating a comfortable work environment for the employees. Their namesake, a scholar rock, which is believed to reveal inner strength and truth, adorns the lobby entrance, greeting all employees and visitors who enter. Touches of wood throughout the space offer a natural and welcoming feel. The open office space provides a selection of glass-paned huddle areas and conference rooms around the building’s core, encouraging employee collaboration and communication. The office space also features layered open ceiling grids, which conceal ductwork and give a sense of place and path amongst the open office areas. A large café doubles as a company assembly space. In the café, two ceiling projectors are cloaked by a wooden shroud, becoming an aerial sculpture and the focus of the café area. The open lab space connects with the office and amenity spaces through shared flooring and ceiling details and integrating the same color palette through accent walls. Additional lab spaces include phage displays, tissue culture rooms, cold rooms, and mass spec.

location

Cambridge, MA

Size

50,000 SF

SERVICES

Tenant Improvements
Visioning
Programming and Planning
Lab Design
Interior Design

A clinical-stage biopharmaceutical company, Scholar Rock, was outgrowing its current space. TRIA was brought on board initially to provide visioning and programming/planning services and subsequently hired for the design to relocate their headquarters.  Scholar Rock’s new 50,000 SF space features a 45/55 lab and office split.

The design focused on implementing branding throughout the space and creating a comfortable work environment for the employees. Their namesake, a scholar rock, which is believed to reveal inner strength and truth, adorns the lobby entrance, greeting all employees and visitors who enter. Touches of wood throughout the space offer a natural and welcoming feel. The open office space provides a selection of glass-paned huddle areas and conference rooms around the building’s core, encouraging employee collaboration and communication. The office space also features layered open ceiling grids, which conceal ductwork and give a sense of place and path amongst the open office areas. A large café doubles as a company assembly space. In the café, two ceiling projectors are cloaked by a wooden shroud, becoming an aerial sculpture and the focus of the café area. The open lab space connects with the office and amenity spaces through shared flooring and ceiling details and integrating the same color palette through accent walls. Additional lab spaces include phage displays, tissue culture rooms, cold rooms, and mass spec.