DPS and TRIA Complete First Phase for Arranta Bio’s Manufacturing Facility

DPS and TRIA Complete First Phase for Arranta Bio’s Manufacturing Facility


December 15, 2020

BOSTON – December 15, 2020 – DPS Group, a privately-owned, global engineering, procurement, construction management, and validation (EPCMV) firm serving high-tech process industries, and TRIA, a principal-led architecture firm with a focus on designing unique spaces for science, technology, and corporate clients, are pleased to announce the completion of the first phase of the 80,000 SF Arranta Bio Manufacturing Facility. Working in partnership with construction manager DC Beane, DPS and TRIA provided architectural, interior design, engineering, and project management services for a new manufacturing facility for microbiome therapeutics located at 650 Pleasant Street in Watertown, Mass. This multi-phase project will be mechanically complete and ready for full occupancy by the end of 2020.

Founded in 2019 with the acquisition of a 10-year old microbiome service provider, Arranta Bio is a contract development and manufacturing organization (CDMO) specifically established to focus on serving companies seeking to develop and commercialize therapeutics targeting the human microbiome. The microbiome refers to the genetic material of literally trillions of microbes – bacteria, fungi, protozoa, and viruses – that live inside and on the human body. Scientists have called it the second genome and over the last decade, there has been a rapid acceleration in scientific understanding of the composition and functions of the gut microbiota. Today, around 200 companies are focused on understanding the human microbiome and its linkage to areas including infectious diseases and oncology, with the goal of identifying therapeutic targets.

“Our goal is to be the leader in our sector. We are doing this with over a decade of experience making live biopharmaceuticals,” said Mark Bamforth, founder, president and CEO of Arranta Bio. “This new manufacturing facility gives us the ability to better support our clients as they continue their work to develop life-enhancing medicine and to bring these through licensure. The combined team of DPS and TRIA – and their deep understanding of our industry – have enabled us to create a facility which will help our clients develop and manufacture promising new Microbiome-based therapies.”

Arranta Bio selected DPS and its design affiliate TRIA to provide design services for the renovation and fit-out of a former warehouse space into a cGMP development and manufacturing facility. Among the many challenges was converting the warehouse building into a state-of-the-art manufacturing space which has the capacity and flexibility to handle a broad range of drug production for Arranta Bio clients. Designed for full process stages along with lyophilization and capsule filling, all new process equipment and building utility equipment were installed along with new clean utility generation. The facility is configured to allow for expansion to larger scale production as demand increases. Current maximum fermentation capacity is 2 x 2000 L, with a total of 13 cGMP suites.  The Arranta Bio facility design allows for agility in process configurations, incorporating single use equipment, strategically located utility panels, and a centralized Vaporized Hydrogen Peroxide (VHP) routed to each room to streamline changeover decontaminations.

“The future of microbiome-based therapy is certainly exciting,” said Aaron Cowley, chief scientific officer for Arranta Bio. “We are uniquely positioned within the microbiome space to facilitate the entire life cycle from bench to market. This new facility allows us to have the technical team that performs basic scientific work on hand to support and troubleshoot a product launch, resulting in shorter timelines and reduced cost and risk.”

When complete, the rear portion building will feature a 9,000 SF research and development (R&D) lab  suite and a 6,000 SF quality control (QC) lab suite on the first floor, with conference rooms, huddle rooms and a large forum/kitchen above on the second floor.  Coordinating the MEP requirements to the first floor lab areas was a another significant challenge with the existing building.  Located right off the parking lot, the front portion of the building will serve as the lobby/reception area and it will include lounge seating, kitchenette, conference rooms, offices, and huddle rooms for use by visitors to the facility. Taking a cue from Arranta Bio’s branding, the look is clean and modern with navy and teal accent colors used throughout the space, helping to create a holistic, cohesive design between lab and office. Open ceiling, patterned carpet, and warm wood toned luxury vinyl tile form a welcoming environment for employees and visitors alike. Upgrades to the exterior included new cladding, exterior lighting, and repairs to the roof. In addition, windows were added on the second floor to bring natural light into the offices and storefront windows were added to the front office.

The project team on Arranta Bio’s manufacturing facility include:

  • Owner: Arranta Bio
  • Construction Manager: DC Beane and Associates Construction Company
  • Architect: TRIA
  • Process Engineer: DPS Group
  • Process Architect: DPS Group
  • MEP Engineers: DPS Group
  • Site and Civil Engineer: VHB
  • Structural Engineers: Goldstein/Milano

About DPS Group

DPS Group is a global engineering, consulting and project management company, serving high-tech industries around the world. DPS delivers services for clients across the complete engineering and construction value chain including feasibility studies, concepts, consulting, architecture, engineering, procurement, construction management, commissioning, qualification and validation, as well as contingent staffing solutions.

DPS applies its extensive process engineering expertise built over 45 years, as well as significant Lean construction experience to assist clients in high-end process sectors such as pharmaceuticals, biotech and semiconductors to deliver manufacturing facilities speedily, safely and cost effectively. What sets the firm apart are the partnerships it builds with clients through a fundamental understanding of their businesses and its own agility, flexibility, original thinking and high-caliber people.

DPS has grown substantially in recent years and now employs more than 1,850 people in 16 offices and on client sites in Ireland, U.K., Netherlands, Belgium, Sweden, Switzerland, Israel, Singapore, Saudi Arabia, and the United States. For more information, visit www.dpsgroupglobal.com.

About TRIA

TRIA is a full-service architecture firm that values client relationships above all. The firm’s principal-driven approach puts our leadership team at the table with client decision-makers, working together to envision success, solve problems and deliver exceptional results. Our lab design and corporate interiors teams strive to learn every client’s unique DNA, and by doing so, we create efficient and energizing spaces that reflect a company’s culture and foster innovation. At TRIA, we design spaces that enable business success and advance new discoveries – in the lab, around the office, and beyond. Visit us on the web at https://tria.design and connect with us on Twitter, LinkedIn, and Facebook.